Technological advancements that provide the opportunity to develop better and more reliable models are essential to translational research. At the FRAME Alternatives Laboratory at the University of Nottingham, PhD candidate Richard Maclennan has been working with the Zyoxel LiverChip device to determine its applicability and limitations for chronic toxicity testing. The LiverChip recreates the in vivo environment of the liver, both in terms of physiology and architecture, in an in vitro model. Small liver samples, including human, can be maintained and tested for upwards of seven days, with future studies investigating the capacity for the cultures to last as long as 28 days. This system could potentially act as a means to refine chronic liver toxicity testing on humans, reduce the number and size of samples required, and ultimately replace the need for animal models.
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