The United States is one of the world’s prominent users of animals for experimental testing. A crucial moment for alternatives occurred in 1966 when the US passed the Animal Welfare Act, which, to this day, is the primary legislation in America regulating the transport, sale, and handling of animals intended to be used for research or other purposes. The AWA has been amended over the decades, yet at its core it has remained the same. There was immense pressure by the public on the government in the 60s to put some form of controlling standard on the use of animals and the implementation of the Animal Welfare Act was an effective move towards this. Many similar pieces of legislation that followed have been to some degree based on the framework put in place by the US.