As the 19th Century progressed, awareness of the controversy surrounding animal testing extended from academic communities into public opinion. Civilian protests, public debates and general uneasiness spread as more knowledge of the conditions, cruelty, and procedures experimental animals were being exposed to was revealed. The first group to rally around the anti-vivisection cause was the National Anti-vivisection Society, founded in London in 1875. This marks a significant moment where the discussion regarding the use of animals in testing entered a much larger arena that included the general public en masse.